Q: Allopurinol can be used as an anti-anginal drug.
A) True
B) False
Answer: A
There is weak evidence that Allopurinol, a xanthine oxidase inhibitor, may be beneficial in stable angina.
It significantly increased the median time to ST depression and the median total exercise time when compared to placebo.
The mechanism of action is proposed to be improved endothelium-dependent vasodilation and the abolition of oxidative stress. The suggested dose is 600 mg per day.
#cardiology
#pharmacology
References:
1. Noman A, Ang DS, Ogston S, et al. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet 2010; 375:2161.
2. Rajendra NS, Ireland S, George J, et al. Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris. J Am Coll Cardiol 2011; 58:820.
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