Hyperalbuminemia and calcium

Q: Hyperalbuminemia can cause hypercalcemia.

A) True

B) False

Answer: A

Although it is very well known that hypoalbuminemia can cause hypocalcemia and various formulae have been invented, it is less emphasized that the reverse is also true, meaning hyperalbuminemia can lead to hypercalcemia. The most common reason is extracellular volume depletion. Another well-recognized clinical scenario is the widespread use of high-protein powders among athletes and 'gym-goers', which may increase serum calcium. It occurs mostly when more than 2 g of protein per kg of body weight per day is consumed.

Said that many experts believe that, just as hypoalbuminemia and hypocalcemia are related and require correction, the same phenomenon applies to hyperalbuminemia and hypercalcemia. The best clinical practice should be to measure ionized calcium.

#electrolytes

References:

1. DENT CE. Some problems of hyperparathyroidism. Br Med J 1962; 2:1419.

2. Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol 2006; 41:759.