Aztreonam cross allergenicity

Q: Which cephalosporin allergy may also cause an allergy to aztreonam? - select one

A) Cefazolin 

B) Cefuroxime 

C) Ceftazidime 

D) Cefepime

E) Ceftaroline 

Answer: C

As a rule of thumb, there is no cross-allergenicity between aztreonam and other beta-lactam antibiotics, except ceftazidime. This cross-allergenicity between aztreonam and ceftazidime allergies is due to a shared side chain, called the R1 side chain.

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References:

Pérez Pimiento A, Gómez Martínez M, Mínguez Mena A, Trampal González A, de Paz Arranz S, Rodríguez Mosquera M. Aztreonam and ceftazidime: evidence of in vivo cross allergenicity. Allergy. 1998 Jun;53(6):624-5. doi: 10.1111/j.1398-9995.1998.tb03944.x. PMID: 9689350.