Dig in pregnancy

Q: Digoxin is contrindicated in pregnancy?

A) Yes

B) No

Answer: B 

Digoxin is one of the unique medicines that is given to the mother for fetal cardiac indications. It crosses the placenta without causing fetal harm or teratogenicity. Moreover, it can be used in lactation for maternal cardiac indications.

It is mostly used to treat sustained fetal tachyarrhythmias, such as supraventricular tachycardia (SVT) and atrial flutter, and to prevent hydrops fetalis.

#ob-gyn

#pharmacology

#pediatrics

#cardiology

References:

1. Hauptman PJ, Kelly RA. Digitalis. Circulation 1999; 99:1265.

2. Wang C, Zhao L, Shao S, Yu H, Zhou S, Li Y, Zhu Q, Liu X, Duan H, Liu H, Hua Y, Zhou K. Transplacental digoxin treatment for fetal supraventricular arrhythmias: Insights from Chinese fetuses. Chin Med J (Engl). 2025 Jun 20;138(12):1499-1501. doi: 10.1097/CM9.0000000000003583. Epub 2025 Apr 9. PMID: 40204513; PMCID: PMC12180843.

3. Soyka LF. Digoxin: placental transfer, effects on the fetus, and therapeutic use in the newborn. Clin Perinatol. 1975 Mar;2(1):23-35. PMID: 1102216.