Delafloxacin

Q: Delafloxacin is a? - select one

A) tetracycline

B) fluoroquinolone

Answer: B

The objective of this question is to make students aware of one of the relatively unknown but potent antibiotics. Delafloxacin is a fluoroquinolone approved for the treatment of bacterial skin and soft tissue infections. 

It has broad-spectrum activity, including methicillin-resistant Staphylococcus aureus (MRSA) (though some resistance has already been reported), Pseudomonas aeruginosa, Enterobacteriaceae, and Clostridioides difficile.

#pharmacology

#ID

References:

1. Candel FJ, Peñuelas M. Delafloxacin: design, development and potential place in therapy. Drug Des Devel Ther 2017; 11:881.

2. Saravolatz LD, Stein GE. Delafloxacin: A New Anti-methicillin-resistant Staphylococcus aureus Fluoroquinolone. Clin Infect Dis 2019; 68:1058.

3. Iregui A, Khan Z, Malik S, et al. Emergence of Delafloxacin-Resistant Staphylococcus aureus in Brooklyn, New York. Clin Infect Dis 2020; 70:1758.

4. O'Riordan W, McManus A, Teras J, et al. A Comparison of the Efficacy and Safety of Intravenous Followed by Oral Delafloxacin With Vancomycin Plus Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Phase 3, Multinational, Double-Blind, Randomized Study. Clin Infect Dis 2018; 67:657.