Q: Which of the following anti-hypertensives should NOT be used in Malignant Hyperthermia (MH)? - select one
A) Beta-Blockers (BBs)
B) Calcium Channel Blockers (CCBs)
Answer: B
CCBs have been shown to worsen hyperkalemia, myocardial depression, and hypotension when co-administered with dantrolene in MH. It is not advisable to initiate CCBs for arrhythmias or hypertension when dantrolene is actively planned.
#pharmacology
References:
1. Rubin AS, Zablocki AD. Hyperkalemia, verapamil, and dantrolene. Anesthesiology 1987; 66:246.
2. Migita T, Mukaida K, Yasuda T, Hamada H, Kawamoto M. Calcium channel blockers are inadequate for malignant hyperthermia crisis. J Anesth. 2012 Aug;26(4):579-84. doi: 10.1007/s00540-012-1347-0. Epub 2012 Feb 16. PMID: 22349750.
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