A note on Octreotide in refractory hypotension

A note on Octreotide in refractory hypotension

Octreotide may have some benefit in refractory vasoplegia and hypotension. Octreotide, when combine with midodrine and albumin, may reverses peripheral vasodilation, particularly in the hepatorenal syndrome. Consequently, it improve renal perfusion and prolong survival. It has also shown to improve postural tachycardia syndrome associated with chronic refractory hypotension.

Reference:

1. Kanjwal K1, Saeed B, Karabin B, Kanjwal Y, Grubb BP. - Use of octreotide in the treatment of refractory orthostatic intolerance. - Am J Ther. 2012 Jan;19(1):7-10. 

2. Skagen C, Einstein M, Lucey MR, Said A (Feb 2009). "Combination Treatment With Octreotide, Midodrine, and Albumin Improves Survival in Patients With Type 1 and Type 2 Hepatorenal Syndrome.". J Clin Gastroenterol. 43 (7): 680–5.