Tuesday, June 18, 2019


Q: In normal physiologic condition, what percentage of platelets are sequestered in the spleen?

Answer: About 33%

Under normal conditions about one-third of circulating platelets are sequestered in the spleen, where they are in equilibrium with circulating platelets. 

Clinical significance: The spleen has an important function related to human circulatory cells. It removes senescent RBCs,  encapsulated organisms, and other particulates from the circulation via monocyte-macrophage system. It is called graveyard of the circulation. Splenectomy due to any reason not only renders the human body to infections but also to venous and arterial thrombosis and pulmonary hypertension.



Crary SE, Buchanan GR. Vascular complications after splenectomy for hematologic disorders. Blood 2009; 114:2861.

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