HE

Q: Hypereosinophilia is defined as? (select one)

A) an absolute eosinophil count (AEC) >1.5 x 109/L separated by at least one week

B) an absolute eosinophil count (AEC) >1.5 x 109/L separated by at least one month

Answer: B

As per experts' consensus Hypereosinophilia (HE) is defined as an absolute eosinophil count (AEC) >1.5 x 109/L (or >1500 cells/microL) in the peripheral blood on two examinations separated in time by at least one month and/or pathologic confirmation of tissue HE. For tissue infiltration it is subjective per the discretion except in case of bone marrow where percentage of eosinophils above 20 percent qualifies as HE.

#hematology

Reference:

1. Valent P, Klion AD, Horny HP, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol 2012; 130:607.