Q: 54 year old male is recovering in ICU from exacerbation of congestive heart failure (CHF). Hydralazine has been added to the drugs regimen. Which one test should be obtained?
Answer: Antinuclear antibody level
Hydralazine carries the risk of drug-induced lupus. It is recommended to check the baseline antinuclear antibody level before starting hydralazine. Also, it should be checked periodically while patient stays on hydralazine.
#pharmacology
#cardiology
References:
1. Finks SW, Finks AL, Self TH. Hydralazine-induced lupus: maintaining vigilance with increased use in patients with heart failure. South Med J. 2006;99(1):18-22.
2. Mansilla-Tinoco R, Harland SJ, Ryan PJ, et al. Hydralazine, antinuclear antibodies, and the lupus syndrome. Br Med J. 1982;284(6320):936-939.
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